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Search Results for " human fibroblasts "

49

抑制剂 & 化合物

11

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T1889	CP-640186 CP 640186	Acetyl-CoA Carboxylase	Metabolism
	CP-640186 是一种有效的乙酰辅酶 A 羧化酶 (ACC)抑制剂，抑制大鼠肝脏 ACC1 和大鼠骨骼肌 ACC2 的 IC50分别为 53 nM 和 61 nM。
T1684	Nitisinone 尼替西农,NTBC,SC0735,Nitisone	Others; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; Others
	Nitisinone (SC0735) 是一种 4-羟基苯丙酮酸双加氧酶抑制剂。
T3622	CP-640186 hydrochloride CP 640186 HCl,盐酸CP-640186	Acetyl-CoA Carboxylase	Metabolism
	CP-640186 hydrochloride (CP 640186 HCl) 是膜渗透性的乙酰辅酶A 羧化酶（ACC）抑制剂，抑制大鼠肝脏ACC1和大鼠骨骼肌ACC2的IC50为53 nM 和61 nM。
T2437	O4I2 O-4I2,O4I2	OCT	Membrane transporter/Ion channel
	O4I2 是一种 Oct3/4诱导剂，可增强多能干细胞相关基因 Lin28、Sox2和 Nanog 的表达，并抑制 Rex1。
T21653	1,4-DPCA	HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism
	1,4-DPCA 是一种脯氨酰羟化酶抑制剂，对人源包皮成纤维细胞中胶原羟基化的 IC50 为 2.4 μM，对因子抑制 HIF (FIH) 的 IC50 为 60 μM。
T36442L	(Hyp³)-Bradykinin acetate (Hyp³)-Bradykinin acetate (37642-65-2 Free base)	Bradykinin Receptor	GPCR/G Protein
	(Hyp³)-Bradykinin acetate 是一种缓激肽 B2 受体激动剂，可刺激培养的人成纤维细胞中磷酸肌醇的产生。
T24706	RBC10 RBC 10,RBC-10	GTPase	GPCR/G Protein
	RBC10 抑制 Ral 与其效应物 RALBP1 的结合，以及抑制 Ral 介导的鼠胚胎成纤维细胞的细胞扩散和人类癌细胞系的非贴壁依赖性生长。
T4100	AS8351 NSC51355,AS-8351,AS 8351	Histone Demethylase	Chromatin/Epigenetic
	AS8351 (NSC51355) 是一种组蛋白去甲基化酶抑制剂，可以诱导人胎儿肺成纤维细胞重编程为功能性心肌细胞。
T38293	4-CPPC	Others	Others
	4-CPPC 是一种巨噬细胞迁移抑制因子 2 (MIF-2; IC50= 27 μM) 的抑制剂。它对 MIF-2 的选择性高于 MIF-1 (IC50= 450 μM)。当以 10 μM 浓度使用时，它在体外抑制 MIF-2，但不抑制 MIF-1，与 CD74 结合。 4-CPPC（5、10 和 25 μM）抑制原代人皮肤成纤维细胞中 MIF-2 诱导的 ERK1/2 磷酸化。
T69502	HSP47 inhibitor III
	HSP47 inhibitor III suppressed collagen type I expression in human and mouse cells and suppressed the viability and migration of lung fibroblasts.
TP2341	Hexapeptide-11 Peptamide 6,Fvapfp,Phe-val-ala-pro-phe-pro
	Hexapeptide-11 is a novel proteostasis network modulator in human diploid fibroblasts.
T30111	AR 12465 AR-12465
	AR 12465 is a trapidil derivative which may affect LDL receptor mediated uptake and degradation of 125 I-LDL by human skin fibroblasts (HSF) and human hepatic cells (HEP G2).
T22490	2,3-DCPE hydrochloride	Others	Others
	Induces p21 expression and S-phase arrest in cancer cells via ERK-mediated pathways. IC50 values are 0.89 and 12.6 μM for LoVo human colon cancer cell line and normal human fibroblasts respectively.
T25055	alpha-RA-F α RA F,alphaRAF,α-RA-F,αRAF
	alpha-RA-F can modulate collagen synthesis and matrix metalloproteinases (MMPs) expression levels by boosting collagen synthesis and reducing MMPs expression levels in human fibroblasts without cytotoxicity.
T30676	C012 Dihydrochloride C-012 Dihydrochloride,C 012 Dihydrochloride,C 012 2HCl,C012 2HCl,C-012 2HCl
	C012 Dihydrochloride is a novel small molecule compound that sensitized BRAF wild-type melanoma cells to verofenib. It can significantly reduce the activity of melanoma cells and has limited toxicity to normal human fibroblasts.
T37853	Cholesteryl Lignocerate
	Cholesteryl lignocerate is a cholesterol ester that has been found in human meibum. Cholesteryl lignocerate can be hydrolyzed by cellular extracts from cultured human skin fibroblasts isolated from healthy individuals but not patients with cholesteryl ester storage disease (CESD) or Wolman disease.
T36495	Conglobatin B
	Conglobatin B is a bacterial metabolite that has been found inStreptomycesMST-91080 and has anticancer activity.1It is cytotoxic to NS-1 mouse myeloma cells (IC50= 0.084 μg/ml) but not NFF human fibroblasts (IC50= >100 μg/ml). 1.Lacey, H.J., Booth, T.J., Vuong, D., et al.Conglobatins B-E: Cytotoxic analogues of the C2-symmetric macrodiolide conglobatinJ. Antibiot. (Tokyo)73(11)756-765(2020)
T36496	Conglobatin C1 Conglobatin C1
	Conglobatin C1 is a bacterial metabolite that has been found inStreptomycesMST-91080 and has anticancer activity.1It is cytotoxic to NS-1 mouse myeloma cells (IC50= 1.05 μg/ml) but not NFF human fibroblasts (IC50= >100 μg/ml). 1.Lacey, H.J., Booth, T.J., Vuong, D., et al.Conglobatins B-E: Cytotoxic analogues of the C2-symmetric macrodiolide conglobatinJ. Antibiot. (Tokyo)73(11)756-765(2020)
T81894	Lys-Phe-Glu-Arg-Gln
	Lys-Phe-Glu-Arg-Gln 促进无血清培养条件下人二倍体成纤维细胞胞浆蛋白的降解作用。
TP2186	PalMitoyl Tripeptide-1	Others	Others
	PalMitoyl Tripeptide-1 对人体皮肤成纤维细胞中胶原蛋白、纤连蛋白和透明质酸的合成有影响，可用于制备抗衰老化妆品。
TP1864	[Glu1]-Fibrinopeptide B [Glu1]-纤维蛋白肽B
	[Glu1]-Fibrinopeptide B, a derivative of fibrinopeptide B amino acid residues 1-14, originates from human fibrinopeptide B (hFpB). hFpB is a proteolytic cleavage product of the fibrinogen B beta-chain, specifically generated by thrombin, which plays a significant role in activating neutrophils (PMN), monocytes, and fibroblasts.
T83853	L-K6L9 TFA
	L-K6L9 是由 L-亮氨酸和 L-赖氨酸的L-异构体组成的溶细胞肽。对LNCaP-CL1 雄激素独立型和22Rv1以及LNCaP雄激素依赖型人类前列腺癌细胞具有细胞毒性（LC50分别为4、4和6 µM），同时也对非癌性NIH3T3小鼠成纤维细胞和OL人类包皮成纤维细胞具有细胞毒性（LC50分别为7和5 µM）。在100 µM的浓度下，引起分离的人类红细胞溶血。
T36073	S-Acetyl-L-glutathione
	S-Acetyl-L-glutathione is a derivative of glutathione .1 It increases intracellular GSH levels in primary fibroblasts derived from patients with glutathione synthetase deficiency when used at a concentration of 50 μM. S-Acetyl-L-glutathione (5 mM) induces apoptosis in Daudi, Raji, and Jurkat lymphoma cells.2 It inhibits the replication of herpes simplex virus 1 (HSV-1) in human foreskin fibroblasts when used at concentrations of 5 and 10 mM.3 S-Acetyl-L-glutathione (6.25 μg/g per day) increases ...
T78030	GRGESP
	GRGESP为胶原凝胶收缩抑制剂，能够抑制人成纤维细胞在胶原凝胶中的扩散，显著减少凝胶收缩，适用于结缔组织形态发生研究。
T73217	Crisnatol BWA770U
	Crisnatol (BWA770U) 为口服有效的抗癌剂，属于芳甲基氨基丙二醇类 DNA 插入剂。该化合物在体外对人类乳腺癌细胞表现出细胞毒性，而对正常人类皮肤成纤维细胞则无显著影响。
T80654	3,3′-Bisdemethylpinoresinol	MMP	Proteases/Proteasome
	3,3′-Bisdemethylpinoresinol，一种木质素类的天然产物，具有抑制UVA照射下人真皮成纤维细胞中MMP-1的活性。该化合物可从Morinda citrifolia种子中分离提取。
T70826	PF-03671148
	PF-03671148 is a potent ALK inhibitor. PF-03671148 inhibits the expression of fibrotic genes and protein markers both in vitro in human fibroblasts and in vivo in a rat wound repair model. Wound healing is not inhibited by the topical application of the ALK5 inhibitor to the wound. PF-03671148 may have potential utility for the prevention of dermal scarring.
TP2186L1	PalMitoyl Tripeptide-1 hydrochloride PalMitoyl Tripeptide-1 hydrochloride(147732-56-7 Free base),棕榈酰三肽-1盐酸盐	Others	Others
	PalMitoyl Tripeptide-1 hydrochloride (PalMitoyl Tripeptide-1 hydrochloride (147732-56-7 Free base)) 对人体皮肤成纤维细胞中胶原蛋白、纤连蛋白和透明质酸的合成有影响，可用于制备抗衰老化妆品。
T78764	Anticancer agent 136	Apoptosis	Apoptosis
	Anticanceragent 136 (compound 22)，一种GDM C17-三唑类似物，对HDF表现出3.38 μM的IC50，与Hsp90有3.86 μM的Kd。本化合物功能为细胞凋亡诱导剂。
T36003	1(R)-(Trifluoromethyl)oleyl alcohol
	1(R)-(Trifluoromethyl)oleyl alcohol is an analog of oleic acid .1It inhibits ferroptosis induced by erastin in primary fibroblasts isolated from patients with Friedreich ataxia, a neuro- and cardiodegenerative disorder characterized by loss or impaired activity of frataxin (FXN), when used at concentrations of 5, 10, or 20 μM. 1(R)-(Trifluoromethyl)oleyl alcohol (5 μM) reduces lipid peroxidation induced byFXNsiRNA knockdown in NBT human myoblasts. 1.Cotticelli, M.G., Forestieri, R., Xia, S., et ...
T34811	Terrein NSC 291308,土曲霉酮,Terrain,(+)Terrein,NSC291308,NSC-291308
	Terrain, also known as NSC 291308, is a fungal metabolite with diverse biological activities. Terrein reduces age-related inflammation induced by oxidative stress through Nrf2/ERK1/2/HO-1 signalling in aged HDF cells. (+)-terrein suppresses interleukin-6/
T78549	Ethylene glycol dimethacrylate	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Ethylene glycol dimethacrylate 是一种具有细胞毒性和基因毒性作用的甲基丙烯酸酯单体。它可增加人牙龈成纤维细胞 (HGF) 内的活性氧 (ROS) 产生，引发 DNA 损伤和细胞凋亡 (apoptosis)，并使细胞周期在 G1/G0 期停滞。
T38045	Cholesterol β-D-Glucoside
	Cholesterol β-D-glucoside is a derivative of cholesterol that contains β-D-glucose . It is formed from cholesterol and glucosylceramide by β-glucosidase 1. It activates heat shock transcription factor 1 (Hsf1) in response to heat shock, which increases the expression of heat shock protein 70 (Hsp70) in TIG-3 human fetal lung fibroblasts when used at a concentration of 10 μM. Cholesterol β-D-glucoside (100 mg/kg) prevents ulcer formation following cold-restraint stress and increases Hsf1 activity...
T71893	Clobetasol Propionate-d5
	Clobetasol propionate-d5 is intended for use as an internal standard for the quantification of clobetasol propionate by GC- or LC-MS. Clobetasol propionate is a corticosteroid. It binds to glucocorticoid receptors in a cell-free assay and inhibits proliferation of primary human skin fibroblasts when used at a concentration of 5 µg/ml. Topical administration of clobetasol propionate reduces croton oil-induced ear edema in mice. Formulations containing clobetasol propionate have been used in the t...
T69055	PD153035 nitrate
	PD153035 is a ATP-competitive EGFR inhibitor with an IC50 and Ki of 25 and 6 pM. PD153035 effectively blocks the enhancement of mitogenesis, induction of early gene expression, and oncogenic transformation that occur in response to EGF receptor stimulation. With human fibroblasts and epidermoid carcinoma cells, PD153035 at nanomolar concentrations rapidly inhibits EGFR autophosphorylation. With breast and ovarian cancer cells, PD153035 not only blocks cell growth via inhibition of EGFR, but also...
T38048	Globotetraosylceramides (porcine RBC)
	Globotetraosylceramides are bioactive neutral glycosphingolipids. They are the major glycolipids in human erythrocytes. They act as receptors for the Shiga toxins Stx1, Stx2, and Stx2e, the cytotoxic protein pierisin-1, and parvovirus B19. Globotetraosylceramides increase the expression of proteins responsible for enamel deposition, including ameloblastin, amelogenin, and enamelin, in dental epithelial cells and activate the ERK and p38 MAPK signaling pathways. Levels of globotetraosylceramides ...
T36929	Pal-KTTKS (acetate)
	Pal-KTTKS is a lipidated pentapeptide consisting of a fragment of the type I collagen C-terminal propeptide conjugated to palmitic acid .1 It increases collagen production in human corneal and dermal fibroblasts when used at concentrations of 0.002, 0.004, and 0.008 wt%.2 Following topical administration, pal-KTTKS (50 μg/cm2) is found in the stratum corneum, epidermis, and dermis of isolated hairless mouse skin.1 It can self-assemble into flat tapes and extended fibrillar structures.3 Pal-KTTKS...
T38042	Resolvin D4 Resolvin D4,RvD4
	Resolvin D4 (RvD4) is a specialized pro-resolving mediator derived from docosahexaenoic acid . [1] It has been detected in human milk, in the dorsal pouch of mice before and after infection with S. aureus, and in untreated tissues from humans, mice, and sardines.[2][3] RvD4, at 10 ng/mouse, reduces neutrophil infiltration in zymosan A-induced peritonitis and, at 200 ng/mouse, diminishes neutrophil infiltration in response to S. aureus infection. [3] With isolated cells, RvD4 promotes phagocytosi...
T82314	GK444	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	GK444（Compound 15a），一种针对HDAC1/2的抑制剂，IC50分别为HDAC1和HDAC2的100 nM与92 nM。其对Caco-2细胞的IC50为4.1μM，并能下调原代正常人肺成纤维细胞中TGF-β1刺激的COL1A1 mRNA水平。此外，GK444还能抑制博来霉素诱发的小鼠肺纤维化。
T79568	NPD-2975	Parasite	Microbiology/Virology
	NPD-2975（化合物30）是一款口服活性的抗锥虫药物，用于治疗非洲人类锥虫病（HAT）。在MRC-5人肺成纤维细胞及T. b. brucei感染的小鼠模型中，NPD-2975毒性低。此化合物展现了良好的代谢稳定性，在体外对T. b. brucei IC500抑制浓度为70 nM。NPD-2975还可抑制CYP450酶，对CYP1A2和CYP2C19的IC50分别为0.16 μM和0.42 μM。
T35982	Capsorubin	Apoptosis; Antiviral	Apoptosis; Immunology/Inflammation
	Capsorubin 是一种类胡萝卜素，具有多种生物活性。Capsorubin 在 167 μM 浓度下，对 2,2′-偶氮(2,4-二甲基戊腈)(AMVN) 诱导的脂质过氧化有抑制作用。capsorubin (1 μM) 可降低 uvb 诱导的人真皮成纤维细胞 DNA 链断裂和凋亡的形成。它还能抑制 Raji 细胞中由12-Carnosine 13-acetate 诱导的 eb 病毒早期抗原 (EBV-EA) 激活。
T70661	Azalanstat mesylate
	Azalanstat is an anti-obesity drug acting as a lanosterol 14α-demethylase inhibitor. Azalanstat has been shown to inhibit cholesterol synthesis in HepG2 cells, human fibroblasts, hamster hepatocytes and hamster liver, by inhibiting the cytochrome P450 enzyme lanosterol 14 alpha-demethylase. When administered orally to hamsters fed regular chow, RS-21607 (50 mg/kg/day) lowered serum cholesterol in a dose-dependent manner (ED50 = 62 mg/kg) in a period of 1 week. It preferentially lowered low densi...
T70660	Azalanstat HCl
	Azalanstat is an anti-obesity drug acting as a lanosterol 14α-demethylase inhibitor. Azalanstat has been shown to inhibit cholesterol synthesis in HepG2 cells, human fibroblasts, hamster hepatocytes and hamster liver, by inhibiting the cytochrome P450 enzyme lanosterol 14 alpha-demethylase. When administered orally to hamsters fed regular chow, RS-21607 (50 mg/kg/day) lowered serum cholesterol in a dose-dependent manner (ED50 = 62 mg/kg) in a period of 1 week. It preferentially lowered low densi...
T83879	1-Arachidoyl Lysophosphatidic Acid sodium 1-Arachidoyl LPA,LPA(20:0),1-Eicosanoyl-Lysophosphatidic Acid
	1-花生四烯酰基溶血磷脂酸（1-arachidoyl LPA）是溶血磷脂酸受体1（LPA1）的激动剂，并且是一种含有花生四烯酸的甘油磷脂，花生四烯酸位于sn-1位置。它能在主要表达LPA1而非LPA2-LPA6的人类肺成纤维细胞中诱导钙离子动员（EC50 = 3.6 µM）。在无细胞试验中，1-Arachidoyl LPA（2.5 µM）还能结合到过氧化物酶体增殖物激活受体γ（PPARγ）的配体结合域。人类尿液中也发现了该化合物。
T35573	Adenosine 5’-methylenediphosphate (hydrate)
	Adenosine 5’-methylenediphosphate is an inhibitor of ecto-5’-nucleotidase, also known as CD73, with a Kivalue of 37 nM.1It inhibits cAMP accumulation induced by adenosine 5’-monophosphate , adenosine 5’-diphosphate , or adenosine 5’-triphosphate but not adenosine in VA-13 human fibroblasts when used at a concentration of 100 μM. Adenosine 5’-methylenediphosphate reduces proliferation of U138MG glioma cells, as well as inhibits the invasion and migration of MHCC97H hepatocellular carcinoma (HCC) ...
T63776	PDE1-IN-4
	PDE1-IN-4 是有效的、选择性的 PDE1 (磷酸二酯酶 -1) 抑制剂，能够作用于 PDE1C (IC50: 10 nM)、PDE1A (IC50: 145 nM) 和 PDE1B (IC50: 354 nM)。PDE1-IN-4 能够调控 cAMP (3′,5′- 环磷酸腺苷) 和 cGMP (3′,5′- 环磷酸鸟苷)，表现出抗纤维化效果。PDE1-IN-4 能够抑制 TGF-β1 诱导的人肺成纤维细胞分化。PDE1-IN-4 能够用于研究特发性肺纤维化 (IPF)。
T74142	Angiotensin II human TFA
	Angiotensin II human (Angiotensin II) TFA 作为肾素/血管紧张素系统中关键的生物活性肽，扮演着血管收缩剂的角色并在调节人体血压中发挥中心作用。其主要通过与 G 蛋白偶联受体 (GPCRs)、血管紧张素 II 1型受体 (AT1R) 和血管紧张素 II 2型受体 (AT2R) 的相互作用来介导效应，包括刺激交感神经系统、增加醛固酮的生物合成和肾脏功能。此外，Angiotensin II human TFA 促进血管平滑肌细胞的生长和 I 型及 III 型胶原在成纤维细胞中的合成，导致血管壁与心肌增厚及纤维化，并诱导细胞凋亡。还通过LOX-1依赖的氧化还原敏感路径诱导内皮细胞中的毛细血管形成。
T83744	Tiger17 TFA H-Trp-Cys-Lys-Pro-Lys-Pro-Lys-Pro-Arg-Cys-His-NH2
	Tiger17是一种环状肽，属于tigerinin-RC1和tigerinin-RC2的衍生物，这两种化合物是在螃蟹吃蛙（F. cancrivora）皮肤分泌物中发现的抗微生物肽。在5至20µg/ml的浓度范围内使用时，Tiger17能增加HaCaT角质形成细胞和人类皮肤成纤维细胞的增殖，并且在20µg/ml的浓度下增加HaCaT细胞的迁移。此外，Tiger17还能增加RAW 264.7巨噬细胞的招募及其TGF-β1和IL-6的分泌。在全层皮肤创伤的小鼠模型中，局部应用20µg/ml的Tiger17能加速伤口闭合和重新上皮化的速度。
T83770	Klotho-derived Peptide 1 (56-87) (human) TFA KP1 (56-87)
	Klotho衍生肽1（KP1）(56-87)是从人类Klotho蛋白质中衍生的肽，具有扰乱TGF-β信号传导的作用。它与TGF-β受体类型1（TGFBR2）和TGF-β受体类型2（TGFBR2；Kds分别为1.41和14.6µM）结合。KP1（10 µg/ml）的预孵育抑制TGF-β在NRK-49F大鼠成纤维细胞中诱导的纤维连接蛋白和α-平滑肌肌动蛋白（α-SMA）水平的增加。在体内，KP1（每天1 mg/kg）选择性地定位于受损的肾脏，并减少血清肌酐和血尿素氮水平，这些是肾功能的标志物，同时也减少了小鼠单侧输尿管阻塞（UUO）和单侧缺血-再灌注损伤诱导的肾脏纤维化模型中的肾纤维化。

化合物

Cat.No: T1889

Synonym: CP 640186

Target: Acetyl-CoA Carboxylase

Cat.No: T1684

Synonym: 尼替西农,NTBC,SC0735,Nitisone

Target: Others, Reactive Oxygen Species

CP-640186 hydrochloride

Cat.No: T3622

Synonym: CP 640186 HCl,盐酸CP-640186

Target: Acetyl-CoA Carboxylase

Cat.No: T2437

Synonym: O-4I2,O4I2

Target: OCT

Cat.No: T21653

Target: HIF/HIF Prolyl-Hydroxylase

(Hyp³)-Bradykinin acetate

Cat.No: T36442L

Synonym: (Hyp³)-Bradykinin acetate (37642-65-2 Free base)

Target: Bradykinin Receptor

Cat.No: T24706

Synonym: RBC 10,RBC-10

Target: GTPase

Cat.No: T4100

Synonym: NSC51355,AS-8351,AS 8351

Target: Histone Demethylase

Cat.No: T38293

Target: Others

HSP47 inhibitor III

Cat.No: T69502

Cat.No: TP2341

Synonym: Peptamide 6,Fvapfp,Phe-val-ala-pro-phe-pro

Cat.No: T30111

Synonym: AR-12465

2,3-DCPE hydrochloride

Cat.No: T22490

Target: Others

Cat.No: T25055

Synonym: α RA F,alphaRAF,α-RA-F,αRAF

C012 Dihydrochloride

Cat.No: T30676

Synonym: C-012 Dihydrochloride,C 012 Dihydrochloride,C 012 2HCl,C012 2HCl,C-012 2HCl

Cholesteryl Lignocerate

Cat.No: T37853

Cat.No: T36495

Cat.No: T36496

Synonym: Conglobatin C1

Lys-Phe-Glu-Arg-Gln

Cat.No: T81894

PalMitoyl Tripeptide-1

Cat.No: TP2186

Target: Others

[Glu1]-Fibrinopeptide B

Cat.No: TP1864

Synonym: [Glu1]-纤维蛋白肽B

Cat.No: T83853

S-Acetyl-L-glutathione

Cat.No: T36073

Cat.No: T78030

Cat.No: T73217

Synonym: BWA770U

3,3′-Bisdemethylpinoresinol

Cat.No: T80654

Target: MMP

Cat.No: T70826

PalMitoyl Tripeptide-1 hydrochloride

Cat.No: TP2186L1

Synonym: PalMitoyl Tripeptide-1 hydrochloride(147732-56-7 Free base),棕榈酰三肽-1盐酸盐

Target: Others

Anticancer agent 136

Cat.No: T78764

Target: Apoptosis

1(R)-(Trifluoromethyl)oleyl alcohol

Cat.No: T36003

Cat.No: T34811

Synonym: NSC 291308,土曲霉酮,Terrain,(+)Terrein,NSC291308,NSC-291308

Ethylene glycol dimethacrylate

Cat.No: T78549

Target: Reactive Oxygen Species

Cholesterol β-D-Glucoside

Cat.No: T38045

Clobetasol Propionate-d5

Cat.No: T71893

PD153035 nitrate

Cat.No: T69055

Globotetraosylceramides (porcine RBC)

Cat.No: T38048

Pal-KTTKS (acetate)

Cat.No: T36929

Cat.No: T38042

Synonym: Resolvin D4,RvD4

Cat.No: T82314

Target: HDAC

Cat.No: T79568

Target: Parasite

Cat.No: T35982

Target: Apoptosis, Antiviral

Azalanstat mesylate

Cat.No: T70661

Cat.No: T70660

1-Arachidoyl Lysophosphatidic Acid sodium

Cat.No: T83879

Synonym: 1-Arachidoyl LPA,LPA(20:0),1-Eicosanoyl-Lysophosphatidic Acid

Adenosine 5’-methylenediphosphate (hydrate)

Cat.No: T35573

Cat.No: T63776

Angiotensin II human TFA

Cat.No: T74142

Cat.No: T83744

Synonym: H-Trp-Cys-Lys-Pro-Lys-Pro-Lys-Pro-Arg-Cys-His-NH2

Klotho-derived Peptide 1 (56-87) (human) TFA

Cat.No: T83770

Synonym: KP1 (56-87)

Cat. No.	Product Name	Target	Signaling Pathways
T4004	Concanavalin A	Apoptosis	Apoptosis
	Concanavalin A 是 Ca2+/Mn2+依赖性和甘露糖/葡萄糖结合植物凝集素。它能够促使程序性细胞死亡。
T5295	1-Hydroxyoctadecane 硬脂醇,1-Octadecanol,Stearyl alcohol,Octadecanol	Others; Endogenous Metabolite	Metabolism; Others
	1-Hydroxyoctadecane (OctadecanolOctadecanol) 是内源性代谢产物的一种。
TN7117	regaloside I	Others	Others
	Regaloside I 是百合中的单体成分,可能是保护人类皮肤成纤维细胞免受 UVA 诱导的形态变化的主要成分。
T3768	Epifriedelanol 表木栓醇,Epifriedelinol	Others	Others
	Epifriedelanol (Epifriedelinol) 是一种分离自 Ulmus davidiana 根皮中的三萜类化合物，具有抗肿瘤作用，可以减缓人原始细胞的衰老。
T5120	Rhamnose 6-Deoxyhexopyranose,L-鼠李糖,6-Deoxy-L-mannose,alpha-L-Rhamnose	Calcium Channel; Endogenous Metabolite	Membrane transporter/Ion channel; Metabolism
	alpha-L-Rhamnose (6-Deoxy-L-mannose) 是存在植物和细菌中的一种单糖。Rhamnose- 免疫原连接物能被用于免疫疗法。Rhamnose 能通过胞外途径穿过上皮细胞，能够作为肠吸收的标志。
T5279	Ethylmalonic acid alpha-Carboxybutyrate,2-Ethylmalonic acid,乙基丙二酸	Others; Endogenous Metabolite	Metabolism; Others
	Ethylmalonic acid (alpha-Carboxybutyrate) 是潜在有毒物质，非致癌性，与神经性厌食和甲氧基脱羧酶缺乏症有关。
T2S2043	Dracorhodin perchlorate Dracorhodin perochlorate,血竭素高氯酸盐,Dracohodin perochlorate	Apoptosis; Others	Apoptosis; Others
	Dracorhodin perchlorate 是来源于中药血竭的一种天然产物。它抑制细胞生长，并以剂量和时间依赖性方式诱导成纤维细胞凋亡，将细胞周期阻滞在 G1 期，可作为抗乳腺癌的候选药物。
T4430	Isosaponarin	Others	Others
	Isosaponarin increases collagen synthesis in human fibroblasts, causes by up-regulated TbetaR-II and P4H production.
TN2177	Sanggenol L	c-Myc; NF-κB	Cell Cycle/Checkpoint; NF-κB
	Sanggenol L shows higher cytotoxicity against human oral tumor cell lines (HSC-2 and HSG) than against normal human gingival fibroblasts (HGF), it induces apoptosis via caspase activation and inhibition of NF-κB/IκBα± phosphorylation as a potent chemother
T36954	Nemorosone
	Nemorosone is a polycyclic polyprenylated acylphloroglucinol (PPAP) originally isolated from C. rosea that has antiproliferative properties.1 Nemorosone inhibits growth of NB69, Kelly, SK-N-AS, and LAN-1 neuroblastoma cells (IC50s = 3.1-6.3 μM), including several drug-resistant clones, but not MRC-5 human embryonic fibroblasts (IC50 = >40 μM).2 It increases DNA fragmentation in LAN-1 cells in a dose-dependent manner, and decreases N-Myc protein levels and phosphorylation of ERK1/2 by MEK1/2. Nem...
TN3616	Cedrelone	Apoptosis; MMP; Antifection	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Cedrelone 是一种柠檬苦素类化合物，是一种吩嗪生物合成样结构域蛋白 (PBLD) 激活剂。Cedrelone 可诱导癌细胞凋亡 (apoptosis)。Cedrelone 是一种非常有效的细胞凋亡诱导剂，它能导致细胞周期停止。Cedrelone 具有杀虫活性，可抑制 P. saucia 的箭毒生长，并可抑制乳草蝽（Oncopeltus fasciatus）的蜕皮。Cedrelone具有抗肿瘤作用，对SMMC-7721、A-549、MCF-7 和 SW480 等癌细胞株具有显著的细胞毒性。

天然产物

Cat.No: T4004

Target: Apoptosis

1-Hydroxyoctadecane

Cat.No: T5295

Synonym: 硬脂醇,1-Octadecanol,Stearyl alcohol,Octadecanol

Target: Others, Endogenous Metabolite

Cat.No: TN7117

Target: Others

Cat.No: T3768

Synonym: 表木栓醇,Epifriedelinol

Target: Others

Cat.No: T5120

Synonym: 6-Deoxyhexopyranose,L-鼠李糖,6-Deoxy-L-mannose,alpha-L-Rhamnose

Target: Calcium Channel, Endogenous Metabolite

Ethylmalonic acid

Cat.No: T5279

Synonym: alpha-Carboxybutyrate,2-Ethylmalonic acid,乙基丙二酸

Target: Others, Endogenous Metabolite

Dracorhodin perchlorate

Cat.No: T2S2043

Synonym: Dracorhodin perochlorate,血竭素高氯酸盐,Dracohodin perochlorate

Target: Apoptosis, Others

Cat.No: T4430

Target: Others

Cat.No: TN2177

Target: c-Myc, NF-κB

Cat.No: T36954

Cat.No: TN3616

Target: Apoptosis, MMP, Antifection

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